Amyloid Proteins, 2 Vols.
The Beta Sheet Conformation and Disease
(Sprache: Englisch)
A first-stop reference on proteins associated with amyloidosis.
This book is the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology. It considers the clinically...
This book is the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology. It considers the clinically...
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Klappentext zu „Amyloid Proteins, 2 Vols. “
A first-stop reference on proteins associated with amyloidosis.This book is the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology. It considers the clinically recognized amyloid proteins that are known to be associated with the amyloid protein folding disorders, dealing with their common structural and thermodynamic features that lead to amyloid fibril formation and disease. Emphasis is on the thermodynamics of protein folding, the structure and physiologic effects of common oligomeric and subfibrillar intermediates and the influence of the extracellular matrix and cellular trafficking and metabolism on the genesis and catabolism of beta pleated sheet proteins.
The chapters on specific amyloid proteins all follow a common structure, allowing quick access to the desired biochemical and medical data, making this an invaluable tool for clinicians and researchers alike.
Inhaltsverzeichnis zu „Amyloid Proteins, 2 Vols. “
OVERVIEW OF AMYLOIDOSIS AND AMLYOID PROTEINS- History and Definition
- Local vs. Systemic Amyloid Proteins
PROTEIN STRUCTURE AND AMYLOIDOSIS
- Amyloidosis by Genetic Mutation
- Sporadic Amyloidosis
- Amyloidosis by Infection
PROTEIN FOLDING,UNFOLDING AND REFOLDING
- Thermodynamics and Protein Conformation
- Posttranslational Modifications
- Serum Amyloid P Component
- Apolipoprotein E
- Proteoglycans of the Extracellular Matrix
PATHWAYS TO AMYLOID FIBRIL FORMATION
&1ially folded globular intermediates
&1ially folded coil intermediates
- Oligomers
PATHOPHYSIOLOGY OF AMYLOID FIBRIL FORMATION
- Oligomers and Cellular Toxicity
- Fibrils and Organ Dysfunction
AMLYLOID PROTEINS
- Beta Amyloid Protein
- Prion Protein
- Amyloid A Protein
- Immunoglobulins
- Apolipoproteins
- Fibrinogen
- Beta-2-microglobulin
- Cystatin
IAPP and other hormones
- (partial contents)
Autoren-Porträt
Jean D. Sipe earned her Ph.D. in Chemistry from the University of Maryland in 1971. She held various positions at the NIH before moving to Boston University in 1980, where she became full professor in 1991. Since 1997 she is also Scientific Review Administrator at the NIH's Center for Scientific Review.Dr. Sipe is a founding editor of the Journal "Amyloid" and was instrumental in establishing a new Gordon Conference on Serum Amyloid A and Amyloidosis.
Bibliographische Angaben
- 2005, 1. Auflage, XXV, 774 Seiten, 129 Schwarz-Weiß-Abbildungen, Maße: 18,6 x 24,6 cm, Gebunden, Englisch
- Herausgegeben: Jean D. Sipe
- Verlag: Wiley-VCH
- ISBN-10: 352731072X
- ISBN-13: 9783527310722
Sprache:
Englisch
Rezension zu „Amyloid Proteins, 2 Vols. “
"Die Fülle und Dichte an Informationen in diesem gut 1.100 Seiten starken Werk ist enorm. Es ist daher ein Muss für alle Experten. Allerdings steht mit diesen beiden Bänden nun auch eine hervorragende Quelle für all diejenigen zur Verfügung, die sich informieren oder in das Gebiet tiefer einsteigen wollen." (Pharmazie in unserer Zeit sowie Die Pharmazie - An International Journal of Pharmaceutical Sciences)
Pressezitat
"Die Fülle und Dichte an Informationen in diesem gut 1.100 Seiten starken Werk ist enorm. Es ist daher ein Muss für alle Experten. Allerdings steht mit diesen beiden Bänden nun auch eine hervorragende Quelle für all diejenigen zur Verfügung, die sich informieren oder in das Gebiet tiefer einsteigen wollen."Pharmazie in unserer Zeit
sowie
Die Pharmazie - An International Journal of Pharmaceutical Sciences
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