Cardiovascular Signaling in Health and Disease

Part 1: Cardiac Signaling.- Chapter 1: Calcium-Dependent Signaling in Cardiac Myocytes.- Chapter 2: Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes.- Chapter 3: Stress Kinase Signaling in Cardiac Myocytes.- Chapter 4: Cardiotoxicity and cardiac cell signaling.- Chapter 5: Protein Phosphatase Signaling in Cardiac Myocytes.- Chapter 6: Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function.- Chapter 7: NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes.- Chapter 8: Lipid Mediators in Cardiovascular Physiology and Disease.- Chapter 9: Cardiac Inflammasome and Arrhythmia.- Chapter 10: Myocardial Fibrosis: Cell Signaling and In Vitro Modeling.- Chapter 11: Neural regulation of cardiac rhythm.- Part 2: Vascular Signaling.- Chapter 12: Mechanisms of lipoproteins and reverse cholesterol transport in atherosclerotic cardiovascular disease.- Chapter 13: Atherosclerotic plaque regression: Future perspective.- Chapter 14: Role of Bioactive Lipid, Phosphatidic Acid in Hypercholesterolemia Drug-induced Myotoxicity - Statin-induced Phospholipase D (PLD) Lipid Signaling in Skeletal Muscle Cells.- Chapter 15: Cell-Cell Communication in the Vascular Endothelium.- Chapter 16: Lysophosphatidic acid regulates endothelial barrier integrity.- Chapter 17: Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators.- Chapter 18: Hyperglycemic Oxoaldehyde (Glyoxal)-induced Vascular Endothelial Cell Damage through Oxidative Stress is protected by Thiol Iron Chelator, Dimercaptosuccinic Acid - Role of Iron in Diabetic Vascular Endothelial Dysfunction.

Narasimham L. Parinandi (pAri) is an Associate Professor in Department of Internal Medicine, The Ohio State University College of Medicine. Parinandi received his B.Sc. (Hons) in botany with chemistry, zoology, English and M.Sc. in Botany with Environmental Biology in Berhampur University, India in 1975-77. From 1977-80, he was a research fellow in Environmental Sciences at the Andhra University, India. He earned his Ph.D. (1986) at the University of Toledo, Toledo, OH in Biology & Toxicology under the tutelage of Prof. Woon H. Jyung, an established zinc metabolism expert and aging biologist. During his graduate training at Toledo, he was exposed to the field of lipids by Prof. Max Funk, an expert lipoxygenase enzymologist from the lineage of Prof. Ned Porter. He did his post-doctoral fellowship (1986-90) at the Hormel Institute, University of Minnesota, the premier lipid institute in USA where he was trained with Prof. Harald Schmid, a celebrity in the area of ether lipids and apioneer in anandamide chemistry. At the Hormel Institute of the University of Minnesota, Parinandi was associated with Prof. Ralph T. Holman (Member of the National Academy of Sciences and Pioneer in Fatty Acid and Lipoxygenase Biochemistry who also coined the name "Omega-3 Fatty Acid") and conducted studies on omega-3 fatty acid dynamics in humans. He was also a research scientist/junior faculty at the Johns Hopkins University School of Medicine (1998-2002) under the mentorship of Prof. V. Natarajan, renowned lipid signaling expert and Prof. Joe G.N. (Skip) Garcia, a celebrated lung vascular biologist. Parinandi has published nearly 125 peer-reviewed original scientific papers, reviews, and book chapters, and edited books on Free Radicals and Antioxidant Protocols with Prof. William Pryor, the legendary Free Radical and Lipid Peroxidation Scientist, Mitochondria in Lung Health and Disease with Prof. Viswanathan Natarajan, a lipid signaling celebrity, and on Measuring Oxidants and