Cyclin-Dependent Kinase (CDK) Inhibitors

Immunoprecipitation of CDK-Cyclin Complexes for Determination of Kinase Activity.- Expression and Purification of Recombinant Cyclins and CDKs for Activity Evaluation.- Expression and Purification of Recombinant CDKs: CDK7, CDK8 and CDK9.- Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination.- Fragment-Based De Novo Design of Cyclin-Dependent Kinase 2 Inhibitors.- Protein-Protein Interaction Inspire the De Novo Design of Cyclin-Dependent Kinases Peptide Inhibitors.- Identification of Cyclin A Binders with a Fluorescent Peptide Sensor.- Cell Synchronization Techniques to Study the Action of CDK Inhibitors.- Analysis of CDK Inhibitors Action on Mitochondria-Mediated Apoptosis.- Evaluating the Effects of CDK Inhibitors in Ischemia-Reperfusion Injury Models.- Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair.- Drug Delivery Strategies of Chemical CDK Inhibitors.- Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs.- Evaluating Chemical CDK Inhibitors as Cell Death Inducers.- Models for the Study of the Crosstalk between Inflammation and Cell Cycle.- Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors.