DNA-Encoded Chemical Libraries

Library Synthesis: Building Block Selection, Handling, and Tracking.- Library Synthesis: Building Block Validation.- Library Synthesis and Analytics.- Chemical Ligation of Oligonucleotide Tags to Support Encoded Chemical Library Synthesis.- On-DNA Reductive Amination and Alkylation.- On-DNA-1,2,3-Triazole Formation via Click Reaction.- On-DNA Suzuki-Miyaura Cross-Coupling.- On-DNA Pd and Cu Promoted C-N Cross-Coupling Reactions.- Palladium Promoted On-DNA Heck Reactions.- Ruthenium Promoted On-DNA C-H Activation Reaction.- DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles.- Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA.- DNA Encoding of Natural Products.- Initiating DNA-Encoded Library Synthesis with a Hexathymidine DNA Oligonucleotide.- One Bead-One Compound (OBOC) Peptidomimetic Encoded Library Synthesis via Split-and-Pool Methods.- DNA Conjugates as Tool Compounds for DEL Selections.- Quantitation of DNA Encoded Libraries by qPCR.- Target Protein Design and Pre-Selection Analysis.- DEL Selections Against a Soluble Protein Target.- Selection Method of DNA-Encoded Chemical Library for Irreversible Covalent Binders.- Next Generation Sequencing of DNA-Encoded Libraries.- Translation of DNA Sequence to Chemical Structure in DNA Encoded Libraries.- Analysis of DNA-Encoded Library Screening Data: Selection of Molecules for Synthesis.- High Throughput Binder Confirmation (HTBC).- High-Throughput Binder Confirmation Using Affinity Selection Mass Spectrometry.