Hematopoietic Stem Cell Transplantation
(Sprache: Englisch)
The field of hematopoietic stem cell transplantation has undergone both evolutionary and dramatic changes over the past 25 years. This is evident by the fact that the term hematopoietic stem cell transplantation has effectively replaced the older term, bone...
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The field of hematopoietic stem cell transplantation has undergone both evolutionary and dramatic changes over the past 25 years. This is evident by the fact that the term hematopoietic stem cell transplantation has effectively replaced the older term, bone marrow transplantation, due to the diverse source of hematopoietic cells that are employed for transplantation. Some of the most significant advances in hematopoietic stem cell transplantation have occurred in the past decade, as our understanding of stem cell biology, hematopoiesis, and immunology have increased. Alternative sources of stem cells, including those from unrelated donors and cord blood, the utilization of less toxic non-myeloablative and reduced-intensity conditioning regimens prior to transplant, and significantly improved supportive care measures have made hematopoietic stem cell transplantation available to greater numbers of patients.
At the same time there have been parallel advances in the treatments of malignancy, which has significantly altered the indications and the role of hematopoietic stem cell transplantation in these diseases, most notably chronic myelogenous leukemia.
This book reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution. It reviews the current clinical indications for the diseases that hematopoietic stem cell transplantation is most commonly utilized. Additional chapters cover the most recent translational research which will affect our future understanding and practice of hematopoietic stem cell transplantation.
At the same time there have been parallel advances in the treatments of malignancy, which has significantly altered the indications and the role of hematopoietic stem cell transplantation in these diseases, most notably chronic myelogenous leukemia.
This book reviews pertinent aspects of both autologous and allogeneic stem cell transplantation and our current understanding of transplantation biology including T cell and natural killer cell biology, HLA expression, and post-transplant immune reconstitution. It reviews the current clinical indications for the diseases that hematopoietic stem cell transplantation is most commonly utilized. Additional chapters cover the most recent translational research which will affect our future understanding and practice of hematopoietic stem cell transplantation.
Klappentext zu „Hematopoietic Stem Cell Transplantation “
The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.
Inhaltsverzeichnis zu „Hematopoietic Stem Cell Transplantation “
Principles and Overview of Allogeneic Hematopoietic Stem Cell Transplantation.- The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation.- Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation.- Advancement and Clinical Implications of HLA Typing in Allogeneic Hematopoietic Stem Cell Transplantation.- Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications.- Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation.- Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells.- Understanding and Enhancing the Graft-Versus-Leukemia Effect After Hematopoietic Stem Cell Transplantation.- Reduced-Intensity and Nonmyeloablative Conditioning Regimens.- Umbilical Cord Blood Transplantation.- Biology and Management of Acute Graft-Versus-Host Disease.- Biology and Management of Chronic Graft-Versus-Host Disease.- Radioimmunoconjugates in Hematopoietic Stem Cell Transplantation.- Evolving Indications for Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Other Plasma Cell Disorders.- Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin's Lymphoma.- The Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma.- Role of Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome.- Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia.- Hematopoietic Stem Cell Transplantation in Children and Adolescents with Malignant Disease.- Cellular Adoptive Immunotherapy After Autologous and Allogeneic HematopoieticStem Cell Transplantation.- Improvements in the Prevention and Management of Infectious Complications After Hematopoietic Stem Cell Transplantation.
Bibliographische Angaben
- 2010, Softcover reprint of hardcover 1st ed. 2009, XV, 589 Seiten, Maße: 15,6 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Michael R. Bishop
- Verlag: Springer, Berlin
- ISBN-10: 1441946187
- ISBN-13: 9781441946188
Sprache:
Englisch
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