Meningococcal Disease
(Sprache: Englisch)
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as...
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Klappentext zu „Meningococcal Disease “
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as feared by parents and family members, as well as the medical staff who have to care for affected patients. The unexpected and unp- dictable occurrence of the disease in previously healthy children and young adults, its rapid progression, and the frequent occurrence of purpura fulminans with the resulting gangrene of limbs and digits and the requirement for mutilating s- gery, have all heightened both public and medical interest in the disease. Over the past two decades there has been a rapid increase in knowledge of many aspects of meningococcal disease as a result of intensive efforts by workers in many different fields: clinicians have studied the early presenting features and acute pathophysiology of the disorder; clinical scientists have explored the immunopathological mechanisms responsible for disease and have highlighted the important roles played by the host inflammatory response and pro-inflammatory cytokines in mediating damage to blood vessels and organs; microbiologists have developed new diagnostic methods; public health phy- cians and epidemiologists have improved surveillance techniques with the help of molecular tools provided by bacterial population biologists; and basic sci- tists have used the powerful new tools in molecular and cell biology to elucidate virulence mechanisms.
Inhaltsverzeichnis zu „Meningococcal Disease “
Microbiology and Laboratory Diagnosis.- Isolation, Culture, and Identification of Meningococci from Clinical Specimens.- PCR Diagnosis.- Detection of Meningococcal Antigen by Latex Agglutination.- Meningococcal Serology.- Antibiotic Susceptibility Testing.- Molecular Approach for the Study of Penicillin Resistance In Neisseria meningitidis.- Overview: Epidemiology, Surveillance, and Population Biology.- Serological Characterization.- Pulsed-Field Gel Electrophoresis.- Nucleotide Sequencing of Antigen Genes of Neisseria meningitidis.- Multi-Locus Sequence Typing.- Capsular Operons.- Molecular Analysis of the Meningococcal LPS Expression.- Genome Sequencing and Annotation.- Representational Difference Analysis.- Managing Outbreaks.- Global Trends in Meningococcal Disease.- Epidemiology, Surveillance, and Population Biology.- Surveillance of Meningococcal Disease in Europe.- Global Surveillance for Meningococcal Disease.- Epidemiology of Meningococcal Disease in North America.- Computational Methods for Meningococcal Population Studies.- Clinical Studies.- Clinical Scoring Systems in Meningococcal Disease.- Quantitative Detection of Bacterial Lipopolysaccharides in Clinical Specimens.- Isolation and Analysis of Radiolabeled Meningococcal Endotoxin.- Cytokine Measurement In Vivo and In Vitro.- Cytokine Bioassays.- Molecular Analysis of Gene-Polymorphisms Affecting the Host Response to Infection.- Coagulation Studies.- Complement Pathways and Meningococcal Disease.- Evaluation of New Treatments for Meningococcal Disease.- Studies on the Effect of Neisserial Porins on Apoptosis of Mammalian Cells.- Molecular Recognition Mechanisms of Meningococci.- Experimental Nasopharyngeal Colonization by Neisseria meningitidis using Explant Organ Culture.- Invasion of the Central NervousSystem by Neisseria meningitidis.- Interactions of Meningococci with Endothelium.- A Promoter Probe Plasmid Based on Green Fluorescent Protein.- Signature-Tagged Mutagenesis.
Bibliographische Angaben
- 2010, XVII, 721 Seiten, Maße: 15,2 x 4,1 cm, Kartoniert (TB), Englisch
- Herausgegeben: Andrew J. Pollard, Martin C.J. Maiden
- Verlag: Springer, Berlin
- ISBN-10: 1617372218
- ISBN-13: 9781617372216
Sprache:
Englisch
Pressezitat
"The editors invited the most skilled specialists in the world, 95 contributors, to share with the readers their knowledge of many aspects of meningococcal disease....The book is a brilliant and comprehensive review of the most recent methods for investigation of meningococcal disease and Neisseria meningitidis. It also includes detailed protocols, which should contribute to standardization of meningococcal investigation in the whole world and should allow different laboratories to obtain comparable results. The book is an excellent source of references. It is highly recommended to microbiologists, epidemiologists and clinicians dealing with meningococcal disease." - Folia Microbiologia"The book claims to be "a comprehensive and authoritative review of meningococcal biology", "an interdisciplinary survey of recent advances and knowledge", to give "cutting-edge methods for the diagnosis, epidemiology and treatment of meningococcal disease", and it fully meets these standards. It has achieved its aim to join basic science with epidemiological and clinical aspects of the disease." - International Journal of Medical Microbiology
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