Neuroprotection and Neuroregeneration for Retinal Diseases

Part I Neuroprotection for Glaucoma.- 1. Molecular Architecture of Glutamate Signaling Pathway in Glaucomatous Optic Neuropathy.- 2. Calcium and Calpain Activation.- 3. Classical Signaling Pathways.- 4. Antioxidative Treatment for Neuroprotection in Glaucoma.- 5. ER stress.- 6. Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation after Optic Nerve Injury.- 7. Neurotrophic factors.- 8. RIP Kinase-Mediated Programmed Necrosis.- 9. Axonal Degeneration.- 10. Axonal Transport.- 11. Interaction Between RGC Bodies and Glia.- 12. Aquaporin in optic neuropathies.- 13. Microglia.- Part II Neuroprotection for Age-Related Macular Degeneration (AMD), Retinal Pigmentary Degeneration.- 14. Neuroprotection for Photoreceptors.- 15. Retinal Photooxidative Stress and Its Modifiers.- 16. Roles of the Retinal Pigment Epithelium in Neuroprotection.- 17. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis; Implication of Light Exposure.- 18. Interaction Between Photoreceptors and RPEs.- Part III Neuroprotection for Other Retinal Diseases.- 19. Neuroprotection for Retinal Detachment.- 20. Neuroinflammation.- 21. Optic Neuritis.- 22. Neuroprotection by Endothelial Progenitor Cells for Retinal Degeneration.- 23. Optic Nerve Regeneration.

Dr. Toru Nakazawa, MD, PhD.

Department of Ophthalmology Tohoku University Graduate School of Medicine

1-1 Seiryo-cho Aoba-ku Sendai-shi Miyagi-ken 980-8574, Japan

Dr. Yasushi Kitaoka, MD, PhD.

Department of Ophthalmology, St. Marianna University School of Medicine

2-16-1 Sugao, Kawasaki-shi, Kanagawa 216-8511, Japan

Dr. Takayuki Harada, MD, PhD.

Visual Research Project Tokyo Metropolitan Institute of Medical Science

2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan

"The book summarizes and reviews recent research findings regarding neuroprotection and neuroregeneration for the treatment of macular degeneration, glaucoma, and retinal diseases. ... The intended audience is medical students, researchers, and ophthalmologists interested in ongoing ophthalmologic research. ... most likely will appeal to ophthalmologists specializing in retinal diseases or glaucoma and to ophthalmologic researchers. ... This is a useful review of the current literature and a convenient summary of ongoing research into macular degeneration, glaucoma, and retinal disease." (Caroline Minkus, Doody's Book Reviews, August, 2015)"This is a great book on the molecular and cellular pathways in retinal diseases and their regeneration through gene, RNA, DNA, and hormonal interventions in human and animal models. ... I recommend this book to ophthalmologists, eye researcher, and physicians with an interest in Retina will benefit greatly." (Joseph J. Grenier, Amazon.com, October, 2014)