Springer Theses / Epoxidations and Hydroperoxidations of ,beta-Unsaturated Ketones
An Approach through Asymmetric Organocatalysis
(Sprache: Englisch)
In this book, Corinna Reisinger describes a new organocatalytic asymmetric epoxidation of cyclic and acyclic a,ß-unsaturated ketones, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant.
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Produktinformationen zu „Springer Theses / Epoxidations and Hydroperoxidations of ,beta-Unsaturated Ketones “
In this book, Corinna Reisinger describes a new organocatalytic asymmetric epoxidation of cyclic and acyclic a,ß-unsaturated ketones, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant.
Klappentext zu „Springer Theses / Epoxidations and Hydroperoxidations of ,beta-Unsaturated Ketones “
Corinna Reisinger has developed a new organocatalytic asymmetric epoxidation of cyclic and acyclic ¿,¿-unsaturated ketones. In this thesis, Corinna documents her methodology, using primary amine salts as catalysts, and hydrogen peroxide as an inexpensive and environmentally benign oxidant. She describes the unprecedented and powerful catalytic asymmetric hydroperoxidation of ¿,¿-enones, a process which produces optically active five-membered cyclic peroxyhemiketals in a single operation. She also proves the versatility and synthetic value of the cyclic peroxyhemiketals by converting them into highly enantioenriched acyclic and cyclic aldol products. Currently, these cyclic aldol products are inaccessible by any other synthetic means. Furthermore, cyclic peroxyhemiketals are precursors to optically active 1,2-dioxolanes which are of biological relevance. This work is a breakthrough in the field of asymmetric epoxidation chemistry and outlines the most efficient method in the literature for generating highly enantioselective cyclic epoxyketones known to date.
Inhaltsverzeichnis zu „Springer Theses / Epoxidations and Hydroperoxidations of ,beta-Unsaturated Ketones “
Background.- Asymmetric Organocatalysis.- Catalytic Asymmetric Epoxidation of Electron-Deficient Olefins.- Synthesis and Relevance of 3-Hydroxy-1,2-dioxolanes and 1,2-Dioxolanes.- Objectives of this Ph.D. Work.- Results and Discussion.- Catalytic Asymmetric Epoxidation of Cyclic Enones.- Catalytic Asymmetric Epoxidation and Hydroperoxidation of Acyclic Enones.- Synthetic Transformations of Optically Active a,ß-Epoxy Ketones and 3-Hydroxy-1,2-dioxolanes.- Summary and Conclusions.- Mechanistic Considerations.- Preparation of Starting Materials.- Catalyst Synthesis.- Summary.- Outlook.- Experimental Part.- General Experimental Conditions.- Catalytic Asymmetric Epoxidation of Cyclic Enones.- Catalytic Asymmetric Hydroperoxidation and Epoxidation of Acyclic Enones.- Synthetic Transformations of Optically Active Products.- Preparation of Starting Materials.- Catalyst Synthesis.
Autoren-Porträt von Corinna Reisinger
Dr. Corinna Reisinger Evonik AG corinna.reisinger@web.de
Bibliographische Angaben
- Autor: Corinna Reisinger
- 2012, XVI, 260 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3642281176
- ISBN-13: 9783642281174
- Erscheinungsdatum: 07.06.2012
Sprache:
Englisch
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