Forensic DNA Typing
Biology and Technology behind STR Markers
(Sprache: Englisch)
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished" reference sequence. The advent of modern DNA technology has resulted...
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Produktinformationen zu „Forensic DNA Typing “
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished" reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing --desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.
Klappentext zu „Forensic DNA Typing “
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished" reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing-desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome
Chapters cover the topic from introductory level right up to "cutting edge" research
High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases
NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions
Inhaltsverzeichnis zu „Forensic DNA Typing “
Ch. 1: Overview & History of DNA TypingCh. 2: DNA Biology Review
Ch. 3: Sample Collection, DNA Extraction, and DNA Quantitation
Ch. 4: The Polymerase Chain Reaction (DNA Amplification)
Ch. 5: Commonly Used Short Tandem Repeat Markers and Commercial Kits
Ch. 6: Biology of STRs
Ch. 7: Forensic Issues
Ch. 8: Single Nucleotide Polymorphisms & Other Bi-allelic Markers
Ch. 9: Y-Chromosome DNA Testing
Ch. 10: Mitochondrial DNA Analysis
Ch. 11: Non-Human DNA and Microbial Forensics
Ch. 12: DNA Separation Methods
Ch. 13: DNA Detection Methods
Ch. 14: Instrumentation for STR Typing
Ch. 15: STR Genotyping Issues
Ch. 16: Laboratory Validation
Ch. 17: New Technologies, Automation, and Expert Systems
Ch. 18: CODIS and DNA Databases
Ch. 19: Basic Genetic Principles, Statistics, & Probability
Ch. 20: STR Population Database Analyses
Ch. 21: Profile Frequency Estimates, Likelihood Ratios & Source Attribution
Ch. 22: Approaches to Statistical Analysis of Mixtures and Degraded DNA
Ch. 23: Kinship and Parentage Testing
Ch. 24: Mass Disaster DNA Victim Identification
App I: Reported STR Alleles
App II: Population Data-STR Allele Frequencies
App. III: Suppliers of DNA Analysis Supplies
App. IV: DAB QA Standards
App. V: DAB Recommendations on Statistics
App. VI: NRC II Recommendations
App. VII: Example DNA Cases
Autoren-Porträt von John M. Butler
John M. Butler is a NIST Fellow and Group Leader at the U.S. National Institute of Standards and Technology, Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has over 100 publications in this field and is a frequent presenter on the topic of DNA typing.
Bibliographische Angaben
- Autor: John M. Butler
- 2000, 688 Seiten, Maße: 20,3 x 25,8 cm, Gebunden, Englisch
- Verlag: Academic Press
- ISBN-10: 0121479528
- ISBN-13: 9780121479527
Sprache:
Englisch
Rezension zu „Forensic DNA Typing “
"When they write the history of forensic science for our times, Forensic DNA Typing will be cited as the classic text on the subject. John Butler's organizational and communication skills have created a book unsurpassed in its abilities to guide a reader through the principles and practices of this complex but critical subject. This book is must reading for forensic educators and their students, and requires a prominent place on the shelf of every forensic and legal practitioner."-Richard Saferstein, Ph.D., Author and Forensic Science Consultant "The much-anticipated second edition of Dr. John Butler's Forensic DNA Typing provides an enormous amount of new and valuable information about DNA typing and the issues associated with this technology. It is a 'must read' for scientists, lawyers, academics, students, police officers or anyone who wants to understand modern DNA testing and the ways in which it has transformed criminal justice systems in the United States and around the world."-Stephen Hogan, Esq., Instructor, Forensic Biology, SUNY-Albany; Faculty Member, DNA Forensics Program, American Prosecutors Research Institute ...it will be clear that the book is an exceptionally comprehensive reference, touching on every relevant aspect of current forensic DNA typing practice. Apart from coverage, the book is well edited, attractively laid out, and makes productive use of its four-color format. Abundant figures and tables help explain and enumerate basic concepts as needed. A feature that is found in several parts of the book that I found particularly appealing is the detailed sourcing of information. This is a very good book, and will serve many practitioners and students of forensic DNA typing as a single source reference. It could also serve as a text for a one semester graduate level course in forensic DNA typing and technology. It is hard to think of a topic in forensic DNA typing that is not treated in the book. Accordingly, it will be a sort of standard
... mehr
reference book in the area. If there are plans to keep the book up to date every few years, it has the potential to become the standard reference, perhaps something akin to Clarke in drugs and toxicology. A final point is that the book is a phenomenal bargain in this day and age at around $80 a copy. There are probably minor things about which one could quibble, but it doesn't seem productive to do so when the overall product is so good. - Journal of Forensic Sciences "Students, lecturers and laboratory workers will all welcome this new edition. At 660 pages it is double the size of the former edition and clearly contains a great deal of new material as well as having been re-arranged. Dr. Butler's book goes far beyond dealing just with high profile cases and mass disasters. He has taken the opportunity in the expanded volume to explain all aspects of DNA typing in greater detail and has produced a volume which is not only informative but high readable. It is as much a book to be enjoyed by the scientist as one to educate and inform. This is a volume which contains something of value to all forensic scientists. It does not talk down to the reader but serves as a balanced guide through the rapidly developing field of DNA studies. It is a book that should be purchased rather than borrowed or just referred to as it is an outstanding guide to the subject. - Journal of Clinical Forensic Medicine
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Pressezitat
When they write the history of forensic science for our times, Forensic DNA Typing will be cited as the classic text on the subject. John Butlers organizational and communication skills have created a book unsurpassed in its abilities to guide a reader through the principles and practices of this complex but critical subject. This book is must reading for forensic educators and their students, and requires a prominent place on the shelf of every forensic and legal practitioner.Richard Saferstein, Ph.D., Author and Forensic Science ConsultantThe much-anticipated second edition of Dr. John Butler's Forensic DNA Typing provides an enormous amount of new and valuable information about DNA typing and the issues associated with this technology. It is a must read for scientists, lawyers, academics, students, police officers or anyone who wants to understand modern DNA testing and the ways in which it has transformed criminal justice systems in the United States and around the world.Stephen Hogan, Esq., Instructor, Forensic Biology, SUNY-Albany; Faculty Member, DNA Forensics Program, American Prosecutors Research Institute
...it will be clear that the book is an exceptionally comprehensive reference, touching on every relevant aspect of current forensic DNA typing practice. Apart from coverage, the book is well edited, attractively laid out, and makes productive use of its four-color format. Abundant figures and tables help explain and enumerate basic concepts as needed. A feature that is found in several parts of the book that I found particularly appealing is the detailed sourcing of information. This is a very good book, and will serve many practitioners and students of forensic DNA typing as a single source reference. It could also serve as a text for a one semester graduate level course in forensic DNA typing and technology. It is hard to think of a topic in forensic DNA typing that is not treated in the book. Accordingly, it will be a sort of standard reference
... mehr
book in the area. If there are plans to keep the book up to date every few years, it has the potential to become the standard reference, perhaps something akin to Clarke in drugs and toxicology. A final point is that the book is a phenomenal bargain in this day and age at around $80 a copy. There are probably minor things about which one could quibble, but it doesnt seem productive to do so when the overall product is so good. - Journal of Forensic Sciences
Students, lecturers and laboratory workers will all welcome this new edition. At 660 pages it is double the size of the former edition and clearly contains a great deal of new material as well as having been re-arranged. Dr. Butlers book goes far beyond dealing just with high profile cases and mass disasters. He has taken the opportunity in the expanded volume to explain all aspects of DNA typing in greater detail and has produced a volume which is not only informative but high readable. It is as much a book to be enjoyed by the scientist as one to educate and inform. This is a volume which contains something of value to all forensic scientists. It does not talk down to the reader but serves as a balanced guide through the rapidly developing field of DNA studies. It is a book that should be purchased rather than borrowed or just referred to as it is an outstanding guide to the subject. Journal of Clinical Forensic Medicine
Students, lecturers and laboratory workers will all welcome this new edition. At 660 pages it is double the size of the former edition and clearly contains a great deal of new material as well as having been re-arranged. Dr. Butlers book goes far beyond dealing just with high profile cases and mass disasters. He has taken the opportunity in the expanded volume to explain all aspects of DNA typing in greater detail and has produced a volume which is not only informative but high readable. It is as much a book to be enjoyed by the scientist as one to educate and inform. This is a volume which contains something of value to all forensic scientists. It does not talk down to the reader but serves as a balanced guide through the rapidly developing field of DNA studies. It is a book that should be purchased rather than borrowed or just referred to as it is an outstanding guide to the subject. Journal of Clinical Forensic Medicine
... weniger
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